Active Transport of Hepatotoxic Pyrrolizidine Alkaloids in HepaRG Cells
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چکیده
منابع مشابه
Pyrrolizidine Alkaloids from Heliotropium
Investigation of the pyrrolizidine alkaloids of Heliotropium arbainense resulted in the isolation and identification of heliotrine, europine and 7-angelylheliotrine. From H. ovalifolium three alkaloids were isolated: supinine, 7-angelylheliotridine and an alkaloid which was shown to be of the heliotridine monoester type with a dehydrated viridifloric acid.
متن کاملPyrrolizidine alkaloids in human diet.
Pyrrolizidine alkaloids are the leading plant toxins associated with disease in humans and animals. Upon ingestion, metabolic activation in liver converts the parent compounds into highly reactive electrophiles capable of reacting with cellular macromolecules forming adducts which may initiate acute or chronic toxicity. The pyrrolizidine alkaloids present a serious health risk to human populati...
متن کاملPyrrolizidine alkaloids in honey and bee pollen.
A total of 3917 honey samples and 119 'bee pollen' samples (pollen collected by honeybees) were analysed for pyrrolizidine alkaloids (PAs). Some 0.05 M sulphuric acid was used for extraction followed by a clean-up step by means of solid-phase extraction. Separation and detection was achieved by target analysis using an LC-MS/MS system. PAs were found in 66% of the raw honeys (bulk honey not yet...
متن کاملPyrrolizidine Alkaloids from Heliotropium indicum
Um novo alcalóide denominado Helindicina (1), e o conhecido licopsamina (2) foram isolados das raízes de Heliotropium indicum (Boraginaceae). As estruturas foram estabelecidas tendo como base um amplo estudo de 1D e 2D RMN (COSY, HMBC, HMQC, NOESY) e HREIMS. Este representa o primeiro relato de um alcalóide contendo um anel lacônico no gênero Heliotropium. Estes alcalóides mostraram moderada at...
متن کاملEvaporative light scattering detection of pyrrolizidine alkaloids.
A reverse-phase high-performance liquid chromatography method utilizing evaporative light scattering detection (ELSD) has been developed for the simultaneous detection of hepatotoxic pyrrolizidine alkaloids with and without chromophores, namely, riddelliine, riddelliine N-oxide, senecionine, senecionine N-oxide, seneciphylline, retrorsine, integerrimine, lasiocarpine and heliotrine. Pyrrolizidi...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: 1422-0067
DOI: 10.3390/ijms22083821